Fermentation-Based · Multi-Grade · Full Documentation

Sodium Hyaluronate Manufacturer & Bulk Supplier

If you are searching for a reliable sodium hyaluronate manufacturer for supplements, cosmetics, medical, or injectable applications, JointSource is your long-term production partner. Full-spectrum molecular weight control, pharmaceutical-grade purification, and customized formulation services.

Why Choose JointSource Sodium Hyaluronate?

JointSource utilizes microbial fermentation technology instead of animal extraction to ensure vegan-friendly production, stable molecular weight distribution, lower endotoxin risk, and higher purity levels.

  • Precision fermentation control & multi-stage purification
  • Ultrafiltration separation & sterile aseptic processing
  • Crosslinking gel manufacturing lines
  • Full molecular weight customization capability
  • GMP, ISO 9001, ISO 22000, ISO 13485, FSSC 22000, HACCP certified manufacturing
6
Molecular Weight Categories
5+
Modified & Derivative Types
60+
Countries Exported
Documentation Available
Certificate of Analysis (COA)
Technical Data Sheet (TDS)
MSDS / Safety Data Sheet
Molecular Weight Distribution Report
Heavy Metal Testing Report
Microbial & Endotoxin Testing
Stability Data

Sodium Hyaluronate — Molecular Weight Range

Select the molecular weight range that matches your formulation target. Each grade page includes full specifications, COA, and application guidance.

🔬

Nano HA

Ultra-Small
< 800 Da

Deepest transdermal penetration — reaches the dermis for true deep-hydration and bio-stimulation. Ideal for high-performance anti-aging serums and cosmeceuticals.

Anti-aging serums
Eye contour products
Cosmeceuticals
View Specifications
⚗️

Hydrolyzed HA

Enzymatic
< 3,000 Da

Enzymatically hydrolyzed for controlled MW and biological activity. Bridges nano and ultra-low range — unique anti-inflammatory and wound-healing properties.

Layered hydration systems
Post-procedure care
Sensitive skin formulations
View Specifications
🔥

Small MW HA

Anti-Inflammatory
< 10,000 Da

Research-backed anti-inflammatory and angiogenic activity. Ideal for cosmeceuticals, wound care, and products targeting sensitive or reactive skin.

Cosmeceuticals
Wound care
Acne & rosacea products
View Specifications
💧

Low MW HA

Most Versatile
10,000 – 400,000 Da

The workhorse grade — optimal for daily moisturizers, oral joint supplements, and functional beverages. Balances skin penetration, hydration, and oral bioavailability.

Daily moisturizers
Joint health supplements
Functional beverages
View Specifications

Medium MW HA

Premium Cosmetic
400,000 – 1,500,000 Da

Premium cosmetic grade with superior viscoelastic properties and intensive surface moisturization. The preferred choice for luxury skincare and professional salon products.

Luxury anti-aging creams
Hydrogel masks
Spa treatments
View Specifications
🦴

High MW HA

Clinical Grade
1,500,000 – 2,200,000 Da

Maximum viscosity — the gold standard for joint viscosupplementation, ophthalmic surgery, and intensive surface moisturization. Mimics native synovial fluid.

Joint injections
Ophthalmic solutions
Intensive moisturizing
View Specifications

Sodium Hyaluronate — Grade Options

Each grade is produced and documented to meet its specific regulatory and application requirements.

🥗
Food Additive / GRAS

Food Grade

Suitable for dietary supplements, functional foods, and nutraceuticals. Meets food safety standards for global supplement markets.

Capsules & tablets
Powder sachets
Functional beverages
View Full Specifications
💄
Cosmetic Standard

Cosmetic Grade

High-purity for topical skincare and cosmetic formulations. Low microbial counts, superior solubility and transparency.

Serums & essences
Moisturizing creams
Facial masks
View Full Specifications
💊
GMP / Pharmacopoeia

Pharmaceutical Grade

Manufactured under strict pharmaceutical GMP. Meets pharmacopoeia standards for finished drug products.

Eye drops
Oral pharma products
Medical gels
View Full Specifications
👁️
Endotoxin-Controlled

Eye-Drop Grade

Sterile-filtered, endotoxin-controlled for ophthalmic applications. Full sterility documentation supplied.

Artificial tears
Ophthalmic solutions
Surgical lubricants
View Full Specifications
💉
Medical Device Standard

Injectable Grade

Ultra-high purity injectable-grade for parenteral use. Comprehensive endotoxin and sterility testing per batch.

Dermal fillers
Joint injections
Viscosupplementation
View Full Specifications

Modified & Derivative Hyaluronate Types

Beyond standard sodium hyaluronate, we supply a full range of modified and derivative forms to meet advanced formulation and application needs.

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Acetylated Hyaluronic Acid

Enhanced lipophilicity through acetylation modification, providing superior affinity to the skin barrier and prolonged moisturizing effect. Particularly suitable for high-end facial serums and barrier-repair formulations.

Key Applications
Premium anti-aging serums
Skin barrier repair creams
Long-lasting moisturizing skincare
Cosmetic Grade View Details →

Cationic Hyaluronic Acid

Quaternary ammonium modification enables strong adsorption to negatively charged hair and skin surfaces, delivering conditioning, anti-static, and film-forming benefits beyond standard HA.

Key Applications
Hair conditioners & shampoos
Scalp care products
Skin-adsorbing cosmetic actives
Cosmetic Grade View Details →
🔗

Crosslinked Hyaluronic Acid

BDDE or DVS crosslinking technology dramatically extends in-vivo residence time and mechanical stability. Available in mono-phase and bi-phase gel formulations for aesthetic and orthopedic applications.

Key Applications
Dermal fillers
Joint viscosupplementation
Ophthalmic surgical gels
Injection / Medical Device Grade View Details →
💧

Hyaluronic Acid (Free Acid Form)

Free acid form of hyaluronic acid with lower pH and unique solubility profile, preferred for specific cosmetic formulations requiring a lower ionic environment or direct acid-form application.

Key Applications
Acidic cosmetic formulas
Specialized dermatology products
Research & biomedical use
Cosmetic / Pharma Grade View Details →
🌿

Potassium Hyaluronate

Potassium salt form of hyaluronic acid, offering comparable moisturizing and skin-plumping performance to sodium hyaluronate with a sodium-free profile — increasingly preferred in clean beauty formulations.

Key Applications
Sodium-free skincare lines
Clean beauty formulations
Sensitive skin products
Cosmetic Grade View Details →
📋

Need a Custom or Unlisted HA Derivative?

We also offer custom modification services and other derivative forms. Contact our technical team with your application requirements.

Enquire Now →

Application Areas & Selection Guide

Match the right sodium hyaluronate specification to your end product application.

💊 Dietary Supplements & Functional Nutrition

Recommended: Low to medium molecular weight (10,000–1,500,000 Da), Food Grade, Powder form.
Used for joint lubrication support, skin hydration supplements, and beauty-from-within formulas.

🧴 Cosmetics & Personal Care

Recommended: Nano / Hydrolyzed / Low MW, Cosmetic Grade or Modified HA, Liquid or powder.
Used for anti-aging skincare, moisturizing serums, facial masks, and scalp care.

💉 Medical, Injectable & Ophthalmic

Recommended: High Molecular Weight, Pharmaceutical or Injection Grade, Sterile solution or gel.
Used for artificial tears, joint viscosupplementation, dermal fillers, and surgical lubrication.

🐾 Veterinary & Animal Health

Recommended: Medium to High Molecular Weight, Pharmaceutical Grade, Injectable or oral supplement form.
Used for animal joint injections, pet joint supplements, and veterinary medical solutions.

Fermentation-Based Manufacturing Technology

JointSource utilizes microbial fermentation technology instead of animal extraction — ensuring vegan-friendly production, stable molecular weight distribution, lower endotoxin risk, and higher purity levels.

  • Precision fermentation control
  • Multi-stage purification
  • Ultrafiltration separation
  • Sterile aseptic processing
  • Crosslinking gel manufacturing lines
  • Custom molecular weight adjustment capability
Request Technical Documents →
🔬
Molecular Weight Control

Precise fermentation parameter management and ultrafiltration fractionation to deliver consistent, customizable molecular weight distribution across all grades.

🧬
HA Modification Technology

Chemical modification capabilities including acetylation, quaternary ammonium grafting, and free acid conversion — enabling enhanced skin affinity, charge interaction, and formulation flexibility.

🔗
Crosslinking Degree Control

BDDE/DVS crosslinking technology with controlled cross-link density, producing gels with tunable viscoelasticity and degradation profiles for aesthetic and orthopedic applications.

⚙️
Crosslinked Microsphere Technology

Advanced microsphere manufacturing for controlled-release injectable applications — uniform particle size distribution and sustained in-vivo performance.

Sodium Hyaluronate FAQs

What molecular weight sodium hyaluronate is best for supplements?+
Low molecular weight (10,000–400,000 Da) is commonly used for dietary supplements targeting joint and skin health, offering a balance of bioavailability and efficacy.
What is the difference between sodium hyaluronate and hyaluronic acid?+
Sodium hyaluronate is the salt form of hyaluronic acid, offering better stability and solubility in formulation applications. It is the preferred form for supplement and cosmetic use.
Can sodium hyaluronate be used for injectable products?+
Yes. Pharmaceutical and medical device grade sodium hyaluronate is used in dermal fillers, ophthalmic solutions, and joint injections under strict regulatory standards.
Do you offer crosslinked hyaluronic gel?+
Yes. We manufacture both mono-phase and bi-phase crosslinked gels for aesthetic medicine applications.
What is your MOQ and lead time?+
MOQ and lead time depend on product grade and customization requirements. Standard grades are available with stable production schedules. Please contact us for specific details.
Do you offer customized molecular weight distribution?+
Yes. We provide customized molecular weight ranges according to your formulation requirements and target application.
Do you support OEM finished product manufacturing?+
Yes. We offer capsule filling, powder packaging, liquid filling, and private label services for qualified customers.

Ready to Source Sodium Hyaluronate?

Contact our team today to request samples, specifications, COA, and compliance documentation.

Request a Quote → Get Free Samples
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