Hydrolyzed HA < 3,000 Da Enzymatic Hydrolysis Cosmetic Grade COA Available

Hydrolyzed Hyaluronic Acid Sodium Hyaluronate < 3,000 Da

Produced via controlled enzymatic hydrolysis of high-MW HA, this sub-3,000 Da fraction offers enhanced skin penetration while retaining the bioactivity of native hyaluronic acid. The optimal balance for layered hydration cosmetics.

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< 3,000 Da
MW Range
Enzymatic
Process
Fermentation
Source
9067-32-7
CAS No.
📄 Documentation: ⬇ COA ⬇ Datasheet 📦 MOQ: 100g  |  🌍 Export Ready  |  ✅ GMP Certified

Hydrolyzed HA — Product Specifications

Controlled enzymatic hydrolysis with consistent MW distribution. Full QC report provided with every batch.

ParameterSpecification
Molecular Weight< 3,000 Da
Production MethodEnzymatic Hydrolysis
AppearanceWhite to off-white powder
Assay (GlcA method)≥ 90%
Loss on Drying≤ 10%
Heavy Metals≤ 20 ppm
Arsenic≤ 2 ppm
Microbial Count≤ 100 CFU/g
pH (1% solution)6.0 – 7.5
SolubilityFreely soluble in water

Why Hydrolyzed HA?

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Enzymatic Precision

Controlled hydrolysis produces a narrow, consistent MW distribution — ensuring reproducible performance across formulation batches.

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Multi-Layer Hydration

At < 3,000 Da, hydrolyzed HA bridges surface and deep-layer moisturization, complementing both nano HA and higher-MW HA in layered systems.

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Bioactive Fragments

Low-MW HA oligomers in this range exhibit unique signaling properties — stimulating angiogenesis and immune-mediated skin regeneration.

Anti-Inflammatory Activity

Research indicates that hydrolyzed HA fragments reduce oxidative stress and inflammation at the dermal level.

Clean Label

Enzyme-derived, no harsh chemical degradation — acceptable for natural and clean-beauty certified formulations.

Recommended Application Areas

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Layered Hydration Systems

Multi-molecular-weight skincare systems combining nano, hydrolyzed, and high-MW HA for comprehensive skin hydration at all depths.

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Premium Facial Serums

Lightweight, fast-absorbing serums with clinical-level hydration and skin-smoothing efficacy.

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Sensitive & Reactive Skin

Gentle formulations for compromised skin barriers — hydrolyzed HA soothes and supports repair without irritation.

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Nutraceutical Supplements

Oral joint health and skin-from-within supplements benefiting from enhanced bioavailability at this MW range.

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Dermal Drug Delivery

Vehicle for transdermal delivery of active cosmetic or pharmaceutical ingredients, improving depth of penetration.

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Post-Procedure Skincare

Soothing and rehydrating preparations for use after laser, peel, or microneedling treatments.

Other Molecular Weight Grades

Nano HA

< 800 Da — deepest penetration for anti-aging serums and cosmeceuticals.

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Low MW HA

10,000 – 400,000 Da — balanced penetration and surface film, versatile for daily moisturizers.

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Medium MW HA

400,000 – 1,500,000 Da — premium cosmetic grade for luxury skincare.

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High MW HA

1,500,000 – 2,200,000 Da — gold standard for joint viscosupplementation.

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Ready to Source Hydrolyzed Hyaluronic Acid?

Contact our team for samples, batch COA, full technical documentation, and pricing based on your required volume and specification.

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