USP Grade Highest Active Shellfish-Derived COA Available

Glucosamine Hydrochloride (HCl)

The most efficient glucosamine form for high-dose supplement manufacturing. Glucosamine HCl provides approximately 83% active glucosamine, enabling smaller dosage forms without compromising efficacy.

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98.0–102.0%
Assay
66-84-2
CAS No.
C₆H₁₃NO₅·HCl
Formula
215.63
MW
📄 Product Documents: ⬇ Certificate of Analysis (COA) ⬇ Product Datasheet ✉ Contact Us to Request

Certificate of Analysis

Based on JointSource enterprise standards. Actual COA provided per batch upon request.

Test Item Result / Specification
Identification & Appearance
Appearance White crystalline powder, odorless, slightly sweet
Specific Rotation +70.0° to +73.0°
Chemical Assay
Assay (dried basis) 98.0% – 102.0%
Physical & Chemical Properties
pH (1% solution) 3.5 – 5.0
Loss on Drying ≤ 0.5%
Residue on Ignition ≤ 0.1%
Sulfate Content ≤ 0.24%
Chloride Content 16.2% – 16.7%
Microbiological
Total Aerobic Count ≤ 1,000 CFU/g
Yeasts & Molds ≤ 100 CFU/g
E. coli Negative
Staphylococcus aureus Negative
Salmonella Negative
Packaging & Storage
Packaging 25 kg/drum (double PE inner bag, fibre drum 330×380mm)
Storage Sealed, cool, dry, clean environment
Shelf Life 24 months

DC Grade (Direct Compression) Available

Granular form with PVP K-30 or HPMC carrier — assay ≥ 95.0%, LOD ≤ 2.0%, heavy metals ≤ 10 ppm. Suitable for direct compression tablet manufacturing. Contact us for DC grade specifications.

Product Advantages

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Highest Active Glucosamine Content

Glucosamine HCl contains approximately 83% active glucosamine per gram — the highest among all glucosamine salt forms, enabling smaller capsule/tablet size at equivalent dosing.

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USP Monograph Compliant

Meets USP monograph for Glucosamine Hydrochloride — the primary standard for the North American supplement market and the most widely used glucosamine form in the US.

Low Hygroscopic

Less moisture-absorbing than sulfate forms — excellent manufacturing stability in tablet and capsule production with reduced caking and flow issues.

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Ultra-Low Ash Content

Residue on ignition ≤ 0.1% — the lowest ash content among all glucosamine forms, confirming the pure HCl salt without additional stabilizing salts.

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DC Grade Available

Direct compression granular grade (with PVP K-30 or HPMC carrier) available for tablet manufacturers requiring direct compression processing without wet granulation.

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Full Documentation

COA, TDS, MSDS, allergen declaration (shellfish), and heavy metal test report available per batch.

Formulation Applications

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US Market Joint Health Supplements

The dominant glucosamine form in the US supplement market — standard ingredient in joint health tablets, capsules, and powder formulas.

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High-Dose Tablet & Capsule Manufacturing

The high active glucosamine content (83%) allows 1,500 mg glucosamine dose in fewer or smaller tablets compared to sulfate forms.

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Glucosamine + Chondroitin + MSM Formulas

The standard combination joint health formula in the US market — JointSource supplies all three active ingredients from a single source.

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Veterinary Joint Health Products

Widely used in canine and feline joint health chews, soft chews, and treats — the preferred form for veterinary joint supplement manufacturers.

Other Glucosamine Forms

Glucosamine Sulfate 2NaCl

Common sodium-stabilized sulfate form for standard joint health capsules.

Learn More →

Glucosamine Sulfate 2KCl

Sodium-free potassium salt form preferred for low-sodium supplement formulations.

Learn More →

N-Acetyl Glucosamine (NAG)

Fermentation-derived, shellfish-free precursor to hyaluronic acid biosynthesis.

Learn More →

Chondroitin Sulfate

The most established synergistic ingredient for joint health supplements.

Learn More →

Ready to Source Glucosamine HCl?

Contact our team to receive samples, batch COA, full technical documentation, and pricing for your production requirements.

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