High MW HA 1,500,000 – 2,200,000 Da Maximum Viscosity Clinical Grade COA Available

High Molecular Weight HA Sodium Hyaluronate 1,500,000 – 2,200,000 Da

The highest viscosity class of sodium hyaluronate — the gold standard for intensive surface moisturization, ophthalmic applications, and joint viscosupplementation. At 1,500,000–2,200,000 Da, it replicates the native synovial fluid environment and forms a thick, protective hydrogel network on skin surfaces.

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1.5M – 2.2M Da
MW Range
Cosmetic / Pharma
Grade
≥ 90%
Assay
9067-32-7
CAS No.
📄 Documentation: ⬇ COA ⬇ Datasheet 📦 MOQ: 500g  |  🌍 Export Ready  |  ✅ GMP Certified

High MW HA — Product Specifications

Produced by precision-controlled fermentation. MW verified by GPC. Available in pharmaceutical-grade with USP/EP compliance on request.

Parameter Specification
Molecular Weight 1,500,000 – 2,200,000 Da
Appearance White powder
Assay (GlcA method) ≥ 90%
Loss on Drying ≤ 10%
Viscosity (1%, 25°C) ≥ 2000 mPa·s
Heavy Metals ≤ 20 ppm
Arsenic ≤ 2 ppm
Microbial Count ≤ 100 CFU/g
pH (1% solution) 6.0 – 7.5
Protein Content ≤ 0.1%

Why High MW HA?

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Maximum TEWL Reduction

High MW HA forms a dense occlusive film on the skin surface — proven to reduce transepidermal water loss by up to 40% in clinical studies.

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Joint Viscosupplementation

Closely mimics native synovial fluid MW (1–10 MDa), making it the preferred grade for intra-articular injection raw materials.

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Ophthalmic Applications

Ultra-high purity, endotoxin-controlled batches available for eye-drop and ocular surgery formulations.

Plumping & Anti-Wrinkle

Maximum surface plumping and wrinkle-filling effect without injection — the most visible cosmetic result of any HA grade.

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Research Standard

Widely used as positive control in HA research for viscosity, water retention, and film-formation studies.

Recommended Application Areas

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Joint Viscosupplementation

Raw material for intra-articular injection products targeting osteoarthritis, knee pain, and joint lubrication.

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Ophthalmic Solutions

Artificial tears, dry eye products, and surgical viscoelastics — where high viscosity and biocompatibility are essential.

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Intensive Moisturizing Creams

Rich, occlusive face and body creams for severely dry, sensitive, and dehydrated skin conditions.

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Wound Care & Dressings

Medical wound care where HA forms a moist, protective environment to promote granulation and reduce scarring.

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Scaffold & Tissue Engineering

High MW HA is used as a biomaterial scaffold in tissue engineering and regenerative medicine research.

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Hydrogel & Gel Formulations

High-viscosity gels for facial treatment masks, pore-minimizing products, and bio-cellulose sheet masks.

Other Molecular Weight Grades

Medium MW HA

400,000 – 1,500,000 Da — premium cosmetic grade with excellent viscoelastic properties.

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Low MW HA

10,000 – 400,000 Da — versatile grade for daily moisturizers and oral supplements.

Learn More →

Crosslinked HA

BDDE/DVS crosslinked — dramatically extended residence time for fillers and joint injections.

Learn More →

Injectable HA

Ultra-high purity sterile grade for dermal fillers and joint injection end-products.

Learn More →

Ready to Source High Molecular Weight Sodium Hyaluronate?

Contact our team for samples, batch COA, GPC reports, and pricing. Pharmaceutical-grade and endotoxin-tested batches available on request.

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