Hydrolyzed HA < 3,000 Da Enzymatic Hydrolysis Cosmetic Grade COA Available

Hydrolyzed Hyaluronic Acid Sodium Hyaluronate < 3,000 Da

Produced via controlled enzymatic hydrolysis of high-MW HA, this sub-3,000 Da fraction offers enhanced skin penetration while retaining the bioactivity of native hyaluronic acid. The optimal balance for layered hydration cosmetics.

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< 3,000 Da
MW Range
Enzymatic
Process
Fermentation
Source
9067-32-7
CAS No.
๐Ÿ“„ Documentation: โฌ‡ COA โฌ‡ Datasheet ๐Ÿ“ฆ MOQ: 100g  |  ๐ŸŒ Export Ready  |  โœ… GMP Certified

Hydrolyzed HA โ€” Product Specifications

Controlled enzymatic hydrolysis with consistent MW distribution. Full QC report provided with every batch.

Parameter Specification
Molecular Weight < 3,000 Da
Production Method Enzymatic Hydrolysis
Appearance White to off-white powder
Assay (GlcA method) โ‰ฅ 90%
Loss on Drying โ‰ค 10%
Heavy Metals โ‰ค 20 ppm
Arsenic โ‰ค 2 ppm
Microbial Count โ‰ค 100 CFU/g
pH (1% solution) 6.0 โ€“ 7.5
Solubility Freely soluble in water

Why Hydrolyzed HA?

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Enzymatic Precision

Controlled hydrolysis produces a narrow, consistent MW distribution โ€” ensuring reproducible performance across formulation batches.

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Multi-Layer Hydration

At < 3,000 Da, hydrolyzed HA bridges surface and deep-layer moisturization, complementing both nano HA and higher-MW HA in layered systems.

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Bioactive Fragments

Low-MW HA oligomers in this range exhibit unique signaling properties โ€” stimulating angiogenesis and immune-mediated skin regeneration.

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Anti-Inflammatory Activity

Research indicates that hydrolyzed HA fragments reduce oxidative stress and inflammation at the dermal level.

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Clean Label

Enzyme-derived, no harsh chemical degradation โ€” acceptable for natural and clean-beauty certified formulations.

Recommended Application Areas

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Layered Hydration Systems

Multi-molecular-weight skincare systems combining nano, hydrolyzed, and high-MW HA for comprehensive skin hydration at all depths.

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Premium Facial Serums

Lightweight, fast-absorbing serums with clinical-level hydration and skin-smoothing efficacy.

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Sensitive & Reactive Skin

Gentle formulations for compromised skin barriers โ€” hydrolyzed HA soothes and supports repair without irritation.

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Nutraceutical Supplements

Oral joint health and skin-from-within supplements benefiting from enhanced bioavailability at this MW range.

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Dermal Drug Delivery

Vehicle for transdermal delivery of active cosmetic or pharmaceutical ingredients, improving depth of penetration.

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Post-Procedure Skincare

Soothing and rehydrating preparations for use after laser, peel, or microneedling treatments.

Other Molecular Weight Grades

Nano HA

< 800 Da โ€” deepest penetration for anti-aging serums and cosmeceuticals.

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Low MW HA

10,000 โ€“ 400,000 Da โ€” balanced penetration and surface film, versatile for daily moisturizers.

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Medium MW HA

400,000 โ€“ 1,500,000 Da โ€” premium cosmetic grade for luxury skincare.

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High MW HA

1,500,000 โ€“ 2,200,000 Da โ€” gold standard for joint viscosupplementation.

Learn More →

Ready to Source Hydrolyzed Hyaluronic Acid?

Contact our team for samples, batch COA, full technical documentation, and pricing based on your required volume and specification.

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